Authors
William J Ripple, Christopher Wolf, Thomas M Newsome, Mauro Galetti, Mohammed Alamgir, Eileen Crist, Mahmoud I Mahmoud, William F Laurance, 15,364 Scientist Signatories from 184 Countries
Publication date
2017/12/1
Journal
BioScience
Volume
67
Issue
12
Pages
1026-1028
Publisher
Oxford University Press
Description
Background. The objective of this study was to determine the efficacy of pegylated interferon (peg-IFN) plus ribavirin (RBV) in human immunodeficiency virus (HIV)–infected patients with hepatitis C virus (HCV)–related compensated liver cirrhosis, as well as the predictors of response in these individuals.
Methods. All subjects enrolled in a prospective cohort of 841 HIV/HCV-coinfected patients who received peg-IFN and RBV and who had a liver biopsy or a liver stiffness measurement within the year before starting peg-IFN plus RBV were included in this study. The sustained virologic response (SVR) rate and predictors of SVR response were analyzed.
Results. A total of 629 patients were included in this study; 175 (28%) had cirrhosis. In an intention-to-treat analysis, 44 (25%) patients with cirrhosis and 177 (39%) without cirrhosis achieved …
Scholar articles
WJ Ripple, C Wolf, TM Newsome, M Galetti, M Alamgir… - BioScience, 2017