Authors
Gilles Thomas, Kevin B Jacobs, Meredith Yeager, Peter Kraft, Sholom Wacholder, Nick Orr, Kai Yu, Nilanjan Chatterjee, Robert Welch, Amy Hutchinson, Andrew Crenshaw, Geraldine Cancel-Tassin, Brian J Staats, Zhaoming Wang, Jesus Gonzalez-Bosquet, Jun Fang, Xiang Deng, Sonja I Berndt, Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun, Carmen Rodriguez, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Edward Giovannucci, Walter C Willett, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni Jr, Robert Hoover, Richard B Hayes, David J Hunter, Stephen J Chanock
Publication date
2008/3
Journal
Nature genetics
Volume
40
Issue
3
Pages
310-315
Publisher
Nature Publishing Group US
Description
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial prospective study—by testing 26,958 SNPs in four independent studies (total of 3,941 cases and 3,964 controls). In the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P < 10−10). In addition, loci on chromosomes 7, 10 (two loci) and 11 were highly significant (between P < 7.31 × 10−13 and P < 2.14 × 10−6). Loci on chromosome 10 include MSMB, which encodes β-microseminoprotein, a primary constituent of semen and a proposed prostate cancer biomarker, and CTBP2, a gene with antiapoptotic activity; the locus on chromosome 7 is at JAZF1, a transcriptional …
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G Thomas, KB Jacobs, M Yeager, P Kraft, S Wacholder… - Nature genetics, 2008