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Frailty and Intrinsic Capacity (IC) are two constructs that depict a comprehensive health measure in older people. While Frailty Phenotype (FP) has often been used to describe health status of people with post-acute sequelae COVID-19 (PASC), IC has never been used to assess the physical and mental capacities a person can draw on in this clinical setting.

This study aims to define an intrinsic capacity index (ICI) for people with PASC starting from validated questionnaires (DASS, EQ-5D-5L, ISI, CD-RISC, and SF-36) that describe the IC 5 health domains including locomotion, sensory, vitality, cognitive and psychosocial. The secondary objective is to demonstrate that our ICI has good sensitivity and, thus, clinical utility to predict PASC recovery within 2-years after infection.

Assuming that the sub-domains explored by the above-mentioned questionnaires were equally important, we leveraged a …