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To identify genomic regions associated with fasting plasma lipid profiles, insulin, glucose, and glycosylated hemoglobin in a Yup'ik study population, and to evaluate whether the observed associations between genetic factors and metabolic traits were modified by dietary intake of marine derived omega‐3 polyunsaturated acids (n‐3 PUFA).

A genome‐wide linkage scan was conducted among 982 participants of the Center for Alaska Native Health Research study. n‐3 PUFA intake was estimated using the nitrogen stable isotope ratio (δ¹⁵N) of erythrocytes. All genotyped SNPs located within genomic regions with LOD scores > 2 were subsequently tested for individual SNP associations with metabolic traits using linear models that account for familial correlation as well as age, sex, community group, and n‐3 PUFA intake. Separate linear models were fit to evaluate interactions between the …