Authors
Laura Kelly Vaughan, Howard W Wiener, Stella Aslibekyan, David B Allison, Peter J Havel, Kimber L Stanhope, Diane M O’Brien, Scarlett E Hopkins, Dominick J Lemas, Bert B Boyer, Hemant K Tiwari
Publication date
2015/6/1
Journal
Metabolism
Volume
64
Issue
6
Pages
689-697
Publisher
WB Saunders
Description
Objective
To identify novel genetic markers of obesity-related traits and to identify gene-diet interactions with n-3 polyunsaturated fatty acid (n-3 PUFA) intake in Yup’ik people.
Material and methods
We measured body composition, plasma adipokines and ghrelin in 982 participants enrolled in the Center for Alaska Native Health Research (CANHR) Study. We conducted a genome-wide SNP linkage scan and targeted association analysis, fitting additional models to investigate putative gene-diet interactions. Finally, we performed bioinformatic analysis to uncover likely candidate genes within the identified linkage peaks.
Results
We observed evidence of linkage for all obesity-related traits, replicating previous results and identifying novel regions of interest for adiponectin (10q26.13-2) and thigh circumference (8q21.11-13). Bioinformatic analysis revealed DOCK1, PTPRE (10q26.13-2) and FABP4 (8q21.11-13) as …
Scholar articles
LK Vaughan, HW Wiener, S Aslibekyan, DB Allison… - Metabolism, 2015