Authors
Laura B Hughes, Dahliann Morrison, James M Kelley, Miguel A Padilla, L Kelly Vaughan, Andrew O Westfall, Harshit Dwivedi, Ted R Mikuls, V Michael Holers, Lezlie A Parrish, Graciela S Alarcón, Doyt L Conn, Beth L Jonas, Leigh F Callahan, Edwin A Smith, Gary S Gilkeson, George Howard, Larry W Moreland, Nick Patterson, David Reich, S Louis Bridges Jr
Publication date
2008/2
Journal
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
Volume
58
Issue
2
Pages
349-358
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Objective
To determine whether shared epitope (SE)–containing HLA–DRB1 alleles are associated with rheumatoid arthritis (RA) in African Americans and whether their presence is associated with higher degrees of global (genome‐wide) genetic admixture from the European population.
Methods
In this multicenter cohort study, African Americans with early RA and matched control subjects were analyzed. In addition to measurement of serum anti–cyclic citrullinated peptide (anti‐CCP) antibodies and HLA–DRB1 genotyping, a panel of >1,200 ancestry‐informative markers was analyzed in patients with RA and control subjects, to estimate the proportion of European ancestry.
Results
The frequency of SE‐containing HLA–DRB1 alleles was 25.2% in African American patients with RA versus 13.6% in control subjects (P = 0.00005). Of 321 patients with RA, 42.1% had at least 1 SE‐containing allele, compared …
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Scholar articles
LB Hughes, D Morrison, JM Kelley, MA Padilla… - Arthritis & Rheumatism: Official Journal of the American …, 2008