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In this paper, the layout of structures under design-dependent pressure loading is optimized using a topology optimization approach. In contrast to topology optimization problems with conventional static external loading, the position and direction of pressure loading are changing with topology of structure during optimization iterations. In order to model the changing structural surface boundaries under design-dependent pressure loading, a pseudo equal-potential function is introduced. Design sensitivity analysis is derived from the adjoint method. Three examples solved by the proposed method are presented.