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In this paper we discuss the response of a braided river to climate and human changes in the last 100 years. Between Gura Humorului and the confluence with Siret River, on a length of about 110 kilometres Moldova River has the features of a braided river channel, supplied with water and coarse sediments by the tributaries which originate from the area of crystalline and flysch mountains. Between years 1910 and 2005, the river channel of Moldova River continuously narrowed on a descendent linear trend until about 76%. At the same time, the marginal vegetation extended its surfaces within the alluvial plain from 38% in 1960, to 71% in 2005. The result is the metamorphosis of river channel from braided to wandering and from wandering to sinuous. The phenomenon has first installed downstream of the extra-Carpathian reach and migrates towards upstream.