Authors
Xue Xu, Jianqiang Li, Jinfeng Zou, Xiaowen Feng, Chao Zhang, Ruiqing Zheng, Weixiang Duanmu, Arnab Saha-Mandal, Zhong Ming, Edwin Wang
Publication date
2019/9/4
Journal
JAMA network open
Volume
2
Issue
9
Pages
e199292-e199292
Publisher
American Medical Association
Description
Importance
Only a small fraction of patients with cancer receiving immune checkpoint therapy (ICT) respond, which is associated with tumor immune microenvironment (TIME) subtypes and tumor-infiltrating lymphocytes (TILs).
Objective
To examine whether germline variants of natural killer (NK) cells, a key component of the immune system, are associated with TIME subtypes, the abundance of TILs, response to ICT, clinical outcomes, and cancer risk.
Design, Setting, and Participants
This genetic association study explored TIME subtypes and examined the association of the germline genomic information of patients with cancer with TIME subtypes, abundance of TILs, response to ICT, prognosis, and cancer risk. Clinical information, tumor RNA sequencing, and whole-exome sequencing (WES) data of paired normal samples of patients with 13 common cancers (n = 5883) were obtained from the Cancer Genome …
Scholar articles
X Xu, J Li, J Zou, X Feng, C Zhang, R Zheng… - JAMA network open, 2019