Authors
Catherine A Hogan, Shangxin Yang, Omai B Garner, Daniel A Green, Carlos A Gomez, Jennifer Dien Bard, Benjamin A Pinsky, Niaz Banaei
Publication date
2021/1/15
Journal
Clinical Infectious Diseases
Volume
72
Issue
2
Pages
239-245
Publisher
Oxford University Press
Description
Background
Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has emerged as an attractive diagnostic modality allowing broad-range pathogen detection, noninvasive sampling, and earlier diagnosis. However, little is known about its real-world clinical impact as used in routine practice.
Methods
We performed a retrospective cohort study of all patients for whom plasma mNGS (Karius test) was performed for all indications at 5 United States institutions over 1.5 years. Comprehensive records review was performed, and standardized assessment of clinical impact of the mNGS based on the treating team’s interpretation of Karius results and patient management was established.
Results
A total of 82 Karius tests were evaluated from 39 (47.6%) adults and 43 (52.4%) children and a total of 53 (64.6%) immunocompromised patients …
Scholar articles
CA Hogan, S Yang, OB Garner, DA Green, CA Gomez… - Clinical Infectious Diseases, 2021