Authors
Gerard Ryan, Myrna B Dolovich, Robin S Roberts, Peter A Frith, Elizabeth F Juniper, Frederick E Hargreave, Michael T Newhouse
Publication date
1981/2
Journal
American Review of Respiratory Disease
Volume
123
Issue
2
Pages
195-199
Publisher
American Lung Association
Description
Comparison of methods of aerosol generation and inhalation is required to improve standardization of inhalation provocation tests. We compared two widely used methods in 10 asthmatics, by measuring the dose and distribution of radiolabeled aerosol deposited in the throat and lung, and the provocation concentration of inhaled histamine required to reduce the FEV1 by 20% (PC20). In one method, aerosol was generated by a Wright nebulizer and inhaled by tidal breathing for 2 min. In the other, aerosol was generated by a DeVilbiss 646 nebulizer attached to a dosimeter, and was inhaled by 5 inspiratory capacity breaths. The measurements with each method were repeated once to determine the reproducibility of results. Both methods deposited the same dose in the lung, but the distribution of the dose was different; the dosimeter method deposited more aerosol in the throat and central airways. The PC20 …
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Scholar articles
G Ryan, MB Dolovich, RS Roberts, PA Frith, EF Juniper… - American Review of Respiratory Disease, 1981