Authors
Richard S Legro, Huiman X Barnhart, William D Schlaff, Bruce R Carr, Michael P Diamond, Sandra A Carson, Michael P Steinkampf, Christos Coutifaris, Peter G McGovern, Nicholas A Cataldo, Gabriella G Gosman, John E Nestler, Linda C Giudice, Phyllis C Leppert, Evan R Myers
Publication date
2007/2/8
Journal
New England Journal of Medicine
Volume
356
Issue
6
Pages
551-566
Publisher
Massachusetts Medical Society
Description
Background
The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior.
Methods
We randomly assigned 626 infertile women with the polycystic ovary syndrome to receive clomiphene citrate plus placebo, extended-release metformin plus placebo, or a combination of metformin and clomiphene for up to 6 months. Medication was discontinued when pregnancy was confirmed, and subjects were followed until delivery.
Results
The live-birth rate was 22.5% (47 of 209 subjects) in the clomiphene group, 7.2% (15 of 208) in the metformin group, and 26.8% (56 of 209) in the combination-therapy group (P<0.001 for metformin vs. both clomiphene and combination therapy; P=0.31 for clomiphene vs. combination therapy). Among pregnancies, the rate of multiple pregnancy …
Total citations
Scholar articles
RS Legro, HX Barnhart, WD Schlaff, BR Carr… - New England Journal of Medicine, 2007
RS Legro, HX Barnhart, WD Schlaff - Journal of Family Practice, 2007