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Effects of social support, negative life events, and daily hassles on depressive symptoms were assessed in 301 adults (aged 65+ yrs), in person 3 times at 6 mo intervals and by mail questionnaires every month over a 12-mo period. Initial social support predicted severity of depressive symptoms 12 mo later. Social support and initial levels of depressive symptomatology predicted number of daily hassles but not number of major life events. Effects of social support, depression, and major life events on the incidence of daily hassles remained significant without the inclusion of hassles reflecting depressive symptomatology or problems in relationships or whose content overlapped with major life events. Daily hassles mediated the effects of major life events on subsequent depression. Results did not differ for men and women. Implications for models of the relations among social support, stress, and depression are …