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The multifaceted defense response of plants involves bioactive natural compounds that recognize, intervene, and neutralize the incoming pathogens. Plant secondary metabolites play roles at different stages of infection and disease progression. Studies have shown the synthesis of specific metabolites to confer resistance or tolerance depending on disease severity and other related factors. However, information on the presence, involvement, and regulation of several metabolites remains largely unavailable. The advent of next-gen omics approaches and the availability of high-throughput metabolomics platforms could expedite the studies in this direction. Given this, the present review details the role of secondary metabolites in plant defense, their modulation to achieve better immunity, and the tools and techniques available to study these metabolites. Further, the review also provides a roadmap for undertaking …