Authors
Ignace Vergote, Jos De Brabanter, Anthony Fyles, Kamma Bertelsen, Nina Einhorn, Paul Sevelda, Martin E Gore, Janne Kærn, Herman Verrelst, Kjerstin Sjövall, Dirk Timmerman, Joos Vandewalle, Marleen Van Gramberen, Claes G Tropé
Publication date
2001/1/20
Journal
The lancet
Volume
357
Issue
9251
Pages
176-182
Publisher
Elsevier
Description
Background
Previous studies on prognostic factors in stage I invasive epithelial ovarian carcinoma have been too small for robust conclusions to be reached. We undertook a retrospective study in a large international database to identify the most important prognostic variables.
Methods
1545 patients with invasive epithelial ovarian cancer (International Federation of Gynaecology and Obstetrics [FIGO] stage I) were included. The records of these patients were examined and data extracted for univariate and multivariate analysis of disease-free survival in relation to various clinical and pathological variables.
Findings
The multivariate analyses identified degree of differentiation as the most powerful prognostic indicator of disease-free survival (moderately vs well differentiated hazard ratio 3·13 [95% CI 1·68–5·85], poorly vs well differentiated 8·89 [4·96–15·9]), followed by rupture before surgery (2·65 [1·53–4·56]), rupture …
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Scholar articles
I Vergote, J De Brabanter, A Fyles, K Bertelsen… - The lancet, 2001