Authors
James M Gardner, Jason J DeVoss, Rachel S Friedman, David J Wong, Ying X Tan, Xuyu Zhou, Kellsey P Johannes, Maureen A Su, Howard Y Chang, Matthew F Krummel, Mark S Anderson
Publication date
2008/8/8
Journal
Science
Volume
321
Issue
5890
Pages
843-847
Publisher
American Association for the Advancement of Science
Description
The prevention of autoimmunity requires the elimination of self-reactive T cells during their development and maturation. The expression of diverse self-antigens by stromal cells in the thymus is essential to this process and depends, in part, on the activity of the autoimmune regulator (Aire) gene. Here we report the identification of extrathymic Aire-expressing cells (eTACs) resident within the secondary lymphoid organs. These stromally derived eTACs express a diverse array of distinct self-antigens and are capable of interacting with and deleting naïve autoreactive T cells. Using two-photon microscopy, we observed stable antigen-specific interactions between eTACs and autoreactive T cells. We propose that such a secondary network of self-antigen–expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection.
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Scholar articles
JM Gardner, JJ DeVoss, RS Friedman, DJ Wong… - Science, 2008