Authors
Daniel B Sloan, Jessica M Warren, Alissa M Williams, Zhiqiang Wu, Salah E Abdel-Ghany, Adam J Chicco, Justin C Havird
Publication date
2018/7/17
Journal
Nature Reviews Genetics
Volume
19
Pages
635-648
Publisher
Nature Publishing Group
Description
The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial and plastid) genomes within eukaryotic cells necessitates coordinated integration between these genomic compartments, with important evolutionary and biomedical implications. Classic questions persist about the pervasive reduction of cytoplasmic genomes via a combination of gene loss, transfer and functional replacement — and yet why they are almost always retained in some minimal form. One striking consequence of cytonuclear integration is the existence of ‘chimeric’ enzyme complexes composed of subunits encoded in two different genomes. Advances in structural biology and comparative genomics are yielding important insights into the evolution of such complexes, including correlated sequence changes and recruitment of novel subunits. Thus, chimeric cytonuclear complexes provide a powerful window into the …
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Scholar articles
DB Sloan, JM Warren, AM Williams, Z Wu… - Nature Reviews Genetics, 2018