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It is unequivocal that the increases in atmospheric carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) since the pre-industrial period are caused by human activities. The accumulation of GHGs in the atmosphere is determined by the balance between anthropogenic emissions, anthropogenic removals, and physical-biogeochemical source and sink dynamics on land and in the ocean. This chapter assesses how physical and biogeochemical processes of the carbon and nitrogen cycles affect the variability and trends of GHGs in the atmosphere as well as ocean acidification and deoxygenation. It identifies physical and biogeochemical feedbacks that have affected (or could affect) future rates of GHG accumulation in the atmosphere, and therefore, influence climate change and its impacts. This chapter also assesses the remaining carbon budget to limit global warming within various goals, as well as the …