Authors
Hirotaka Iwaki, Cornelis Blauwendraat, Mary B Makarious, Sara Bandrés‐Ciga, Hampton L Leonard, J Raphael Gibbs, Dena G Hernandez, Sonja W Scholz, Faraz Faghri, International Parkinson's Disease Genomics Consortium (IPDGC), Mike A Nalls, Andrew B Singleton, Alastair J Noyce, Rauan Kaiyrzhanov, Ben Middlehurst, Demis A Kia, Manuela Tan, Henry Houlden, Huw R Morris, Helene Plun‐Favreau, Peter Holmans, John Hardy, Daniah Trabzuni, John Quinn, Vivien Bubb, Kin Y Mok, Kerri J Kinghorn, Nicholas W Wood, Patrick Lewis, Sebastian Schreglmann, Ruth Lovering, Lea R'Bibo, Claudia Manzoni, Mie Rizig, Mina Ryten, Sebastian Guelfi, Valentina Escott‐Price, Viorica Chelban, Thomas Foltynie, Nigel Williams, Karen E Morrison, Carl Clarke, Alexis Brice, Fabrice Danjou, Suzanne Lesage, Jean‐Christophe Corvol, Maria Martinez, Claudia Schulte, Kathrin Brockmann, Javier Simón‐Sánchez, Peter Heutink, Patrizia Rizzu, Manu Sharma, Thomas Gasser, Mark R Cookson, Sara Bandres‐Ciga, Cornelis Blauwendraat, David W Craig, Kimberley Billingsley, Derek Narendra, Faraz Faghri, J Raphael Gibbs, Dena G Hernandez, Kendall Van Keuren‐Jensen, Joshua M Shulman, Hirotaka Iwaki, Hampton L Leonard, Mike A Nalls, Laurie Robak, Jose Bras, Rita Guerreiro, Steven Lubbe, Steven Finkbeiner, Niccolo E Mencacci, Codrin Lungu, Andrew B Singleton, Sonja W Scholz, Xylena Reed, Roy N Alcalay, Ziv Gan‐Or, Guy A Rouleau, Lynne Krohn, Jacobus J van Hilten, Johan Marinus, Astrid D Adarmes‐Gómez, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Francisco Javier Barrero, Jesús Alberto Bergareche Yarza, Inmaculada Bernal‐Bernal, Marta Blazquez, Marta Bonilla‐Toribio, Juan A Botía, María Teresa Boungiorno, Dolores Buiza‐Rueda, Ana Cámara, Fátima Carrillo, Mario Carrión‐Claro, Debora Cerdan, Jordi Clarimón, Yaroslau Compta, Monica Diez‐Fairen, Oriol Dols‐Icardo, Jacinto Duarte, Raquel Duran, Francisco Escamilla‐Sevilla, Mario Ezquerra, Cici Feliz, Manel Fernández, Rubén Fernández‐Santiago, Ciara Garcia, Pedro García‐Ruiz, Pilar Gómez‐Garre, Maria Jose Gomez Heredia, Isabel Gonzalez‐Aramburu, Ana Gorostidi Pagola, Janet Hoenicka, Jon Infante, Silvia Jesús, Adriano Jimenez‐Escrig, Jaime Kulisevsky, Miguel A Labrador‐Espinosa, Jose Luis Lopez‐Sendon, Adolfo López de Munain Arregui, Daniel Macias, Irene Martínez Torres, Juan Marín, Maria Jose Marti, Juan Carlos Martínez‐Castrillo, Carlota Méndez‐del‐Barrio, Manuel Menéndez González, Marina Mata, Adolfo Mínguez, Pablo Mir, Elisabet Mondragon Rezola, Esteban Muñoz, Javier Pagonabarraga, Pau Pastor, Francisco Perez Errazquin, Teresa Periñán‐Tocino, Javier Ruiz‐Martínez, Clara Ruz, Antonio Sanchez Rodriguez, María Sierra, Esther Suarez‐Sanmartin, Cesar Tabernero, Juan Pablo Tartari, Cristina Tejera‐Parrado, Eduard Tolosa
Publication date
2020/5
Journal
Movement Disorders
Volume
35
Issue
5
Pages
774-780
Publisher
John Wiley & Sons, Inc.
Description
Background
Although the leucine‐rich repeat kinase 2 p.G2019S mutation has been demonstrated to be a strong risk factor for PD, factors that contribute to penetrance among carriers, other than aging, have not been well identified.
Objectives
To evaluate whether a cumulative genetic risk identified in the recent genome‐wide study is associated with penetrance of PD among p.G2019S mutation carriers.
Methods
We included p.G2019S heterozygote carriers with European ancestry in three genetic cohorts in which the mutation carriers with and without PD were selectively recruited. We also included the carriers from two data sets: one from a case‐control setting without selection of mutation carriers and the other from a population sampling. Associations between polygenic risk score constructed from 89 variants reported recently and PD were tested and meta‐analyzed. We also explored the interaction of age …
Scholar articles
H Iwaki, C Blauwendraat, MB Makarious… - Movement Disorders, 2020