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Climate shapes geographic and seasonal patterns in global fire activity by mediating vegetation composition, productivity, and desiccation in conjunction with land‐use and anthropogenic factors. Yet, the degree to which climate variability affects interannual variability in burned area across Earth is less understood. Two decades of satellite‐derived burned area records across forested and nonforested areas were used to examine global interannual climate–fire relationships at ecoregion scales. Measures of fuel aridity exhibited strong positive correlations with forested burned area, with weaker relationships in climatologically drier regions. By contrast, cumulative precipitation antecedent to the fire season exhibited positive correlations to nonforested burned area, with stronger relationships in climatologically drier regions. Climate variability explained roughly one‐third of the interannual variability in burned area …