Authors
Konstantinos Gerasimidis, Martin Bertz, Laura Hanske, Jana Junick, Olga Biskou, Margarita Aguilera, Vikki Garrick, Richard K Russell, Michael Blaut, Paraic McGrogan, Christine A Edwards
Publication date
2014/5/1
Journal
Inflammatory bowel diseases
Volume
20
Issue
5
Pages
861-871
Publisher
LWW
Description
Background
The gut microbiota is implicated in the pathogenesis of Crohn’s disease (CD). Exclusive enteral nutrition (EEN) is a successful treatment, but its mode of action remains unknown. This study assessed serial changes in the fecal microbiota milieu during EEN.
Methods
Five fecal samples were collected from CD children: 4 during EEN (start, 15, 30, end EEN approximately 60 days) and the fifth on habitual diet. Two samples were collected from healthy control subjects. Fecal pH, bacterial metabolites, global microbial diversity abundance, composition stability, and quantitative changes of total and 7 major bacterial groups previously implicated in CD were measured.
Results
Overall, 68 samples were from 15 CD children and 40 from 21 control subjects. Fecal pH and total sulfide increased and butyric acid decreased during EEN (all P < 0.05). Global …
Scholar articles
K Gerasimidis, M Bertz, L Hanske, J Junick, O Biskou… - Inflammatory bowel diseases, 2014