Authors
Rinse K Weersma, Pieter CF Stokkers, Adriaan A van Bodegraven, Ruud A van Hogezand, Hein W Verspaget, Dirk J de Jong, CJ Van Der Woude, Bas Oldenburg, RK Linskens, EAM Festen, Gerrit van der Steege, Daan W Hommes, JBA Crusius, Cisca Wijmenga, Ilja M Nolte, Gerard Dijkstra, Dutch Initiative on Crohn and Colitis (ICC
Publication date
2009/3/1
Journal
Gut
Volume
58
Issue
3
Pages
388-395
Publisher
BMJ Publishing Group
Description
Background
Crohn’s disease and ulcerative colitis have a complex genetic background. We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD).
Methods
We studied 2804 patients (1684 with Crohn’s disease and 1120 with ulcerative colitis) and 1350 controls from seven university hospitals. Details of the phenotype were available for 1600 patients with Crohn’s disease and for 800 with ulcerative colitis. Genetic association for disease susceptibility was tested for the nucleotide-binding and oligomerisation domain 2 gene (NOD2), the IBD5 locus, the Drosophila discs large homologue 5 and autophagy-related 16-like 1 genes (DLG5 and ATG16L1) and the interleukin 23 receptor gene (IL23R). Interaction analysis was performed for Crohn’s disease using the most …
Total citations
Scholar articles
RK Weersma, PCF Stokkers, AA van Bodegraven… - Gut, 2009