Authors
Guido H Dolmans, Paul M Werker, Hans C Hennies, Dominic Furniss, Eleonora A Festen, Lude Franke, Kerstin Becker, Pieter van der Vlies, Bruce H Wolffenbuttel, Sigrid Tinschert, Mohammad R Toliat, Michael Nothnagel, Andre Franke, Norman Klopp, H-Erich Wichmann, Peter Nürnberg, Henk Giele, Roel A Ophoff, Cisca Wijmenga
Publication date
2011/7/28
Journal
New England Journal of Medicine
Volume
365
Issue
4
Pages
307-317
Publisher
Massachusetts Medical Society
Description
Background
Dupuytren's disease is a benign fibromatosis of the hands and fingers that leads to flexion contractures. We hypothesized that multiple genetic and environmental factors influence susceptibility to this disease and sought to identify susceptibility genes to better understand its pathogenesis.
Methods
We conducted a genomewide association study of 960 Dutch persons with Dupuytren's disease and 3117 controls (the discovery set) to test for association between the disease and genetic markers. We tested the 35 single-nucleotide polymorphisms (SNPs) most strongly associated with Dupuytren's disease (P<1×10−4) in the discovery set in three additional, independent case series comprising a total of 1365 affected persons and 8445 controls from Germany, the United Kingdom, and the Netherlands.
Results
Initially, we observed a significant genomewide association between Dupuytren's disease and …
Total citations
Scholar articles
GH Dolmans, PM Werker, HC Hennies, D Furniss… - New England Journal of Medicine, 2011