Authors
Eleonora AM Festen, Philippe Goyette, Regan Scott, Vito Annese, Alexandra Zhernakova, Jing Lian, Celine Lefebvre, Steven R Brant, Judy H Cho, Mark S Silverberg, Kent D Taylor, Dirk J De Jong, Pieter C Stokkers, Dermot McGovern, Orazio Palmieri, Jean-Paul Achkar, Ramnik J Xavier, Mark J Daly, Richard H Duerr, Cisca Wijmenga, Rinse K Weersma, John D Rioux
Publication date
2009/6/1
Journal
Gut
Volume
58
Issue
6
Pages
799-804
Publisher
BMJ Publishing Group
Description
Objectives
Genetic susceptibility is known to play a large part in the predisposition to the inflammatory bowel diseases (IBDs) known as Crohn’s disease (CD) and ulcerative colitis (UC). The IL2/IL21 locus on 4q27 is known to be a common risk locus for inflammatory disease (shown in coeliac disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and psoriasis), while the roles that interleukin 2 (IL2) and IL21 play in the immune response also make them attractive candidates for IBD. The objective of this study was to test for association between the IL2/IL21 locus and the IBDs.
Methods
The four single nucleotide polymorphisms (SNPs) in the IL2/IL21 locus most associated with coeliac disease were genotyped in 1590 subjects with IBD and 929 controls from The Netherlands, and then replicated in a North American cohort (2387 cases and 1266 controls) and an Italian cohort (805 cases and 421 …
Total citations
Scholar articles
EAM Festen, P Goyette, R Scott, V Annese… - Gut, 2009