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Despite the many known health benefits of exercise, there is a body of evidence suggesting that endurance exercise is associated with oxidative stress. To determine whether extreme endurance exercise induces lipid peroxidation, 11 athletes (3 females, 8 males) were studied during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) 1 month later. The evening before each trial, with dinner, subjects consumed 75 mg each d₃-RRR and d₆-all rac-α-tocopheryl acetates. Blood was obtained at baseline, 30 min pre-race, mid-race, post-race, 1 h post-race, 24 h post-race, and at corresponding times during trial 2. All 11 subjects completed the race; average run time was 391 ± 23 min. Plasma F₂-isoprostanes increased from 75 ± 7 pg/ml at pre-race to 131 ± 17 (p < .02) at post-race, then returned to baseline at 24 h post-race; F₂-isoprostanes were unchanged during trial 2. Deuterated α-tocopherol …