Authors
Jeremie Calais, Francesco Ceci, Matthias Eiber, Thomas A Hope, Michael S Hofman, Christoph Rischpler, Tore Bach-Gansmo, Cristina Nanni, Bital Savir-Baruch, David Elashoff, Tristan Grogan, Magnus Dahlbom, Roger Slavik, Jeannine Gartmann, Kathleen Nguyen, Vincent Lok, Hossein Jadvar, Amar U Kishan, Matthew B Rettig, Robert E Reiter, Wolfgang P Fendler, Johannes Czernin
Publication date
2019/9/1
Journal
The Lancet Oncology
Volume
20
Issue
9
Pages
1286-1294
Publisher
Elsevier
Description
Background
National Comprehensive Cancer Network guidelines consider 18F-fluciclovine PET-CT for prostate cancer biochemical recurrence localisation after radical prostatectomy, whereas European Association of Urology guidelines recommend prostate-specific membrane antigen (PSMA) PET-CT. To the best of our knowledge, no prospective head-to-head comparison between these tests has been done so far. The aim of this study was to compare prospectively paired 18F-fluciclovine and PSMA PET-CT scans for localising biochemical recurrence of prostate cancer after radical prostatectomy in patients with low prostate-specific antigen (PSA) concentrations (<2·0 ng/mL).
Methods
This was a prospective, single-centre, open-label, single-arm comparative study done at University of California Los Angeles (Los Angeles, CA, USA). Patients older than 18 years of age with prostate cancer biochemical recurrence …
Scholar articles
J Calais, F Ceci, M Eiber, TA Hope, MS Hofman… - The Lancet Oncology, 2019