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Environmental variance (V_E) is partially under genetic control, which means that the V_E of individuals that share the same environment can differ because they have different genotypes. Previously, a divergent selection experiment for V_E of litter size (LS) during 13 generations in rabbit yielded a successful response and revealed differences in resilience between the divergent lines. The aim of the current study was to identify signatures of selection in these divergent lines to better understand the molecular mechanisms and pathways that control V_E of LS and animal resilience. Three methods (F_ST, ROH and varLD) were used to identify signatures of selection in a set of 473 genotypes from these rabbit lines (377) and a base population (96). A whole-genome sequencing (WGS) analysis was performed on 54 animals to detect genes with functional mutations …