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In the major zones of crustal deformation within the Arabia-Sinai-Nubia plates, the interactions between the Sinai-Negev Shear Zone (SNSZ) and the Dead Sea Fault system (DSF) shed light on the interplay between neighboring, large-scale fault systems.The SNSZ is composed of several ~E-W to ENE–WSW trending, mainly normal and dextral, strike-slip faults that are tens to hundreds of kilometers long. These faults form a ~ 120 km wide shear zone in the Sinai sub-plate. On reaching the plate-bounding Dead Sea Fault system (DSF), individual lineaments of the SNSZ are observed in the Arabian plate offset left-laterally by 105 km, which is the total estimated offset of the DSF. In this contribution, we review the geologic setting of the SNSZ and its complex relations with the DSF in light of newly obtained age-strain analyses. For this we use in-situ U-single bondPb geochronology in conjunction with twin analysis of …