Authors
Larry A Allen, G Michael Felker, Mandeep R Mehra, Jun R Chiong, Stephanie H Dunlap, Jalal K Ghali, Daniel J Lenihan, Ron M Oren, Lynne E Wagoner, Todd A Schwartz, Kirkwood F Adams Jr
Publication date
2010/3/1
Journal
Journal of cardiac failure
Volume
16
Issue
3
Pages
230-238
Publisher
Churchill Livingstone
Description
BACKGROUND
Adverse outcomes have recently been linked to elevated red cell distribution width (RDW) in heart failure. Our study sought to validate the prognostic value of RDW in heart failure and to explore the potential mechanisms underlying this association.
METHODS AND RESULTS
Data from the Study of Anemia in a Heart Failure Population (STAMINA-HFP) registry, a prospective, multicenter cohort of ambulatory patients with heart failure supported multivariable modeling to assess relationships between RDW and outcomes. The association between RDW and iron metabolism, inflammation, and neurohormonal activation was studied in a separate cohort of heart failure patients from the United Investigators to Evaluate Heart Failure (UNITE-HF) Biomarker registry. RDW was independently predictive of outcome (for each 1% increase in RDW, hazard ratio for mortality 1.06, 95% CI 1.01-1.12; hazard ratio …
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Scholar articles
LA Allen, GM Felker, MR Mehra, JR Chiong… - Journal of cardiac failure, 2010