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Despite the vast number of people who use technology as a part of their spiritual practice, there is little research on the subject in studies of Human–Computer Interaction (HCI). Although HCI takes the idea of user experience very seriously, the field gives almost no consideration to experiences with technology that might be described as spiritual or transcendent. This paper reviews the work that HCI has produced in this area, but also draws on related research in psychology, philosophy, sociology, anthropology, digital religion, psychopharmacology, and neuroscience. The literature indicates that transcendent experiences can be facilitated physically (through natural environments, architecture, art, music), chemically (with psychedelic compounds such as psilocybin, LSD, ketamine, and mescaline), and also digitally (in virtual reality, meditation apps, and research prototypes). While there are a wide range of perspectives within the literature, many terms recur describing transcendence as: ineffable, intense, ephemeral, paradoxical and sometimes sacred; mystical transcendent experiences are characterized by unity, epiphany, and an altered perception of time and space; common emotional responses include ecstasy, tranquility, gratitude, awe, and reverence. Such experiences are similar across religious and cultural backgrounds but interpretations vary according to world view. Studies record benefits of transcendent experiences such as substance use recovery and improved mental health. We explore the themes in the literature through an illustrated design fiction depicting a near-future conference on transcendent experience (TX) research. This …