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Rural communities in developing countries are faced with many challenges due to its geographical and demographic conditions. This has been evident in many studies and surveys. Health issues are among the top priority challenges in governments’ agendas. One important example is the vaccination of new born babies and young children. Vaccination is generally considered to be the most effective method for preventing infectious diseases. The rate for nonvaccination is much higher among communities in rural and remote regions. Information and Communications Technology can play an important role in assisting the government to manage the process and help reduce the rate of nonvaccination. In this paper, we describe a mobile system developed to electronically manage the vaccination process. Early evaluation demonstrates the benefits of such system in supporting government activities.