Authors
Jessica J Manson, Colin Crooks, Meena Naja, Amanda Ledlie, Bethan Goulden, Trevor Liddle, Emon Khan, Puja Mehta, Lucia Martin-Gutierrez, Kirsty E Waddington, George A Robinson, Liliana Ribeiro Santos, Eve McLoughlin, Antonia Snell, Christopher Adeney, Ina Schim van der Loeff, Kenneth F Baker, Christopher JA Duncan, Aidan T Hanrath, B Clare Lendrem, Anthony De Soyza, Junjie Peng, Hajar J'Bari, Mandy Greenwood, Ellie Hawkins, Hannah Peckham, Michael Marks, Tommy Rampling, Akish Luintel, Bryan Williams, Michael Brown, Mervyn Singer, Joe West, Elizabeth C Jury, Matthew Collin, Rachel S Tattersall
Publication date
2020/10/1
Journal
The Lancet Rheumatology
Volume
2
Issue
10
Pages
e594-e602
Publisher
Elsevier
Description
Background
A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.
Methods
In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein concentration greater than 150 mg/L or doubling within 24 h from greater than 50 mg/L, or a ferritin concentration greater than …
Scholar articles
JJ Manson, C Crooks, M Naja, A Ledlie, B Goulden… - The Lancet Rheumatology, 2020