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SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience SIR, We present the case of a 24-year-old female of Pakistani origin with an SLE-like illness secondary to complete C1q deficiency, treated successfully with fresh frozen plasma (FFP) therapy since the age of 15 years. Her clinical presentation has been previously reported [1]. She presented at the age of 6 years with cutaneous lupus and developed seizures secondary to cerebral lupus at the age of 11 years. Despite treating with prednisolone (15mg/day) and AZA (75mg/day), her disease remained active at the age of 15 years. Clinical features included fatigue, fever, arthralgia, mucosal ulceration, headache, malar rash, weight loss and amenorrhea. She had also developed fungal nail infections and recurrent urinary and respiratory bacterial infections. Examination findings included Cushingoid appearance, malar rash, alopecia, oral …