Authors
Luke Furtado O’Mahony, Arnav Srivastava, Puja Mehta, Coziana Ciurtin
Publication date
2021/6/1
Source
Rheumatology
Volume
60
Issue
6
Pages
2602-2614
Publisher
Oxford University Press
Description
Objectives
The aetiology of primary chronic pain syndromes (CPS) is highly disputed. We performed a systematic review and meta-analysis aiming to assess differences in circulating cytokine levels in patients with diffuse CPS (fibromyalgia) vs healthy controls (HC).
Methods
Human studies published in English from the PubMed, MEDLINE/Scopus and Cochrane databases were systematically searched from inception up to January 2020. We included full text cross-sectional or longitudinal studies with baseline cytokine measurements, reporting differences in circulating cytokine levels between fibromyalgia patients and HC. Random-effects meta-analysis models were used to report pooled effects and 95% CIs. This study is registered with PROSPERO (CRD42020193774).
Results
Our initial search yielded 324 papers and identified 29 studies (2458 …
Total citations
Scholar articles
LF O'Mahony, A Srivastava, P Mehta, C Ciurtin - Rheumatology, 2021