Authors
Michaela C Pascoe, Sheila G Crewther, Leeanne M Carey, David P Crewther
Publication date
2011/4
Source
International Journal of Stroke
Volume
6
Issue
2
Pages
128-135
Publisher
SAGE Publications
Description
Ischaemic stroke often precedes the appearance of clinical depression. Poststroke depression in turn influences the prognostic outcome. In the interest of advancing our understanding of the biological mechanisms underlying the development of poststroke depression, this systematic review explores the immunological processes driving the development of inflammation-related cell death in mood-related brain regions. Particular attention has been paid to cytokine-driven intrinsic apoptosis factors, including intracellular calcium, glutamate excitotoxicity and free radicals that appear in the brain following ischaemic damage and whose presence significantly increases the likelihood of clinically defined depression.
Total citations
Scholar articles
MC Pascoe, SG Crewther, LM Carey, DP Crewther - International Journal of Stroke, 2011