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Epithelial mesenchymal transition (EMT) is a process by which transformed epithelial cells undergo changes to a more mesenchymal phenotype, thereby enhancing metastasis. We examined effects of beta-adrenergic signaling and/or biobehavioral exposures on EMT polarization in primary ovarian tumor cells and in exosomes, cell-derived vesicles involved in intercellular signaling. Exosomal profiles from 40 ovarian cancer patients with low vs. high social support were examined for EMT polarization. We recently reported a significant up-regulation of 67 mesenchymal-characteristic gene transcripts and down-regulation of 63 epithelial-characteristic transcripts in exosomes of patients with low levels of social support, demonstrating increased EMT polarization (p = 0.0002). Here, genome-wide transcriptome profiling of advanced stage ovarian tumors from 98 patients was performed, and EMT profiles of those …