Authors
Robin Wood, Hua Liang, Hulin Wu, Keren Middelkoop, Tollulah Oni, Molebogeng X Rangaka, Robert J Wilkinson, Linda-Gail Bekker, Stephen D Lawn
Publication date
2010/4/1
Journal
The international journal of tuberculosis and lung disease
Volume
14
Issue
4
Pages
406-412
Publisher
International Union Against Tuberculosis and Lung Disease
Description
SETTING
Crowded townships of Cape Town, South Africa, where human immunodeficiency virus (HIV) prevalence and tuberculosis (TB) notification rates are among the highest in the world.
OBJECTIVES
To determine age-specific prevalence rates of latent tuberculosis infection (LTBI) among HIV-negative individuals, and the annual risk and force of infection during childhood and adolescence.
DESIGN
A cross-sectional survey using a standardised tuberculin skin test (TST) in HIV-negative individuals aged 5–40 years. A TST diameter of ≥10 mm was defined as indicative of LTBI.
RESULTS
Among 1061 individuals, only 4.7% had low-grade TST responses of 1–9 mm. However, the proportions of individuals with TST ≥10 mm increased from 28.0% in the 5–10 year age stratum to 88.0% in the 31–35 year age stratum. The mean annual risk of infection was 3.9% up to 5 years of age. The estimated force of infection …
Total citations
Scholar articles
R Wood, H Liang, H Wu, K Middelkoop, T Oni… - The international journal of tuberculosis and lung …, 2010