Authors
Philip N Newsome, Magali Sasso, Jonathan J Deeks, Angelo Paredes, Jérôme Boursier, Wah-Kheong Chan, Yusuf Yilmaz, Sébastien Czernichow, Ming-Hua Zheng, Vincent Wai-Sun Wong, Michael Allison, Emmanuel Tsochatzis, Quentin M Anstee, David A Sheridan, Peter J Eddowes, Indra N Guha, Jeremy F Cobbold, Valérie Paradis, Pierre Bedossa, Véronique Miette, Céline Fournier-Poizat, Laurent Sandrin, Stephen A Harrison
Publication date
2020/4/1
Journal
The lancet Gastroenterology & hepatology
Volume
5
Issue
4
Pages
362-373
Publisher
Elsevier
Description
Background
The burden of non-alcoholic fatty liver disease (NAFLD) is increasing globally, and a major priority is to identify patients with non-alcoholic steatohepatitis (NASH) who are at greater risk of progression to cirrhosis, and who will be candidates for clinical trials and emerging new pharmacotherapies. We aimed to develop a score to identify patients with NASH, elevated NAFLD activity score (NAS≥4), and advanced fibrosis (stage 2 or higher [F≥2]).
Methods
This prospective study included a derivation cohort before validation in multiple international cohorts. The derivation cohort was a cross-sectional, multicentre study of patients aged 18 years or older, scheduled to have a liver biopsy for suspicion of NAFLD at seven tertiary care liver centres in England. This was a prespecified secondary outcome of a study for which the primary endpoints have already been reported. Liver stiffness measurement (LSM) by …
Scholar articles
PN Newsome, M Sasso, JJ Deeks, A Paredes… - The lancet Gastroenterology & hepatology, 2020