Authors
Mohammed Eslam, Reynold Leung, Manuel Romero-Gomez, Alessandra Mangia, William L Irving, David Sheridan, Ulrich Spengler, Lindsay Mollison, Wendy Cheng, Elisabetta Bugianesi, Duncan McLeod, Abed M Zaitoun, Vito Attino, Diane Goeltz, Jacob Nattermann, Mark Douglas, David R Booth, Jacob George, Golo Ahlenstiel
Publication date
2014/8/1
Journal
Journal of hepatology
Volume
61
Issue
2
Pages
235-241
Publisher
Elsevier
Description
Background & Aims
Single nucleotide polymorphisms (SNPs) near the interferon lambda 3 (IFNL3, previously known as IL28B) region are the strongest baseline predictors of sustained virologic response (SVR) to pegylated interferon and ribavirin therapy in hepatitis C virus (HCV) genotype 1 infection. Whether IFNL3 SNPs influence treatment response in genotype 2 and 3 (HCV-2/3) infection remains controversial. This study sought to clarify in a large cohort, whether SNPs in the IFNL3 region are associated with treatment response in HCV-2/3 patients.
Methods
The cohort comprised 1002 HCV-2/3 Caucasians patients treated with pegylated interferon-alpha and ribavirin who underwent genotyping for the SNPs rs12979860 and rs8099917.
Results
Overall, 736 (73.5%) patients achieved SVR (81.9%, 67.9%, and 57.8% for rs12979860 CC, CT, and TT [p = 0.0001]; 78%, 68.7%, and 46.3% for rs8099917 TT, TG, and …
Scholar articles
M Eslam, R Leung, M Romero-Gomez, A Mangia… - Journal of hepatology, 2014