Authors
Avner Thaler, Moran Artzi, Anat Mirelman, Yael Jacob, Rick C Helmich, Bart FL van Nuenen, Tanya Gurevich, Avi Orr‐Urtreger, Karen Marder, Susan Bressman, Bastiaan R Bloem, Talma Hendler, Nir Giladi, Dafna Ben Bashat, LRRK2 Ashkenazi Jewish Consortium
Publication date
2014/5
Journal
Movement Disorders
Volume
29
Issue
6
Pages
823-827
Description
Background
Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub‐cortical structures, yet changes in the pre‐motor phase of the disease are unknown.
Methods
A comprehensive imaging study using voxel‐based morphometry and diffusion tensor imaging tract‐based spatial statistics analysis was performed on 64 Ashkenazi Jewish asymptomatic first degree relatives of patients with Parkinson's disease (30 mutation carriers), who carry the G2019S mutation in the leucine‐rich repeat kinase 2 (LRRK2) gene.
Results
No between‐group differences in gray matter volume could be noted in either whole‐brain or volume‐of‐interest analysis. Diffusion tensor imaging analysis did not identify group differences in white matter areas, and volume‐of‐interest analysis identified no differences in diffusivity parameters in Parkinson's disease‐related structures …
Scholar articles
A Thaler, M Artzi, A Mirelman, Y Jacob, RC Helmich… - Movement Disorders, 2014