Authors
Harneek Chohan, Konstantin Senkevich, Radhika K Patel, Jonathan P Bestwick, Benjamin M Jacobs, Sara Bandres Ciga, Ziv Gan‐Or, Alastair J Noyce
Publication date
2021/6
Journal
Movement disorders
Volume
36
Issue
6
Pages
1420-1429
Publisher
John Wiley & Sons, Inc.
Description
Background
Type 2 diabetes (T2DM) and Parkinson's disease (PD) are prevalent diseases that affect an aging population. Previous systematic reviews and meta‐analyses have explored the relationship between diabetes and the risk of PD, but the results have been conflicting.
Objective
The objective was to investigate T2DM as a determinant of PD through a meta‐analysis of observational and genetic summary data.
Methods
A systematic review and meta‐analysis of observational studies was undertaken by searching 6 databases. We selected the highest‐quality studies investigating the association of T2DM with PD risk and progression. We then used Mendelian randomization (MR) to investigate the causal effects of genetic liability toward T2DM on PD risk and progression, using summary data derived from genome‐wide association studies.
Results
In the observational part of the study, pooled effect …
Scholar articles
H Chohan, K Senkevich, RK Patel, JP Bestwick… - Movement disorders, 2021