Authors
Steffen Pabel, Maria Knierim, Thea Stehle, Felix Alebrand, Michael Paulus, Marcel Sieme, Melissa Herwig, Thomas Koertl, Brisca Wenner, Senka Ljubojevic-Holzer, Nataliya Dybkova, Simon Sedej, Daniel Scherr, Christoph Brochhausen, Gerd Hasenfuss, Lars S Maier, Nazha Hamdani, Katrin Streckfuss-Bömeke, Samuel Sossalla
Publication date
2021/11/16
Journal
Circulation
Volume
144
Issue
Suppl_1
Pages
A12001-A12001
Publisher
Lippincott Williams & Wilkins
Description
Introduction: The effects of atrial fibrillation (AF) on left ventricular (LV) function are poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to LV dysfunction. This study investigated the effects of AF on the human LV.
Methods and Results: LV myocardium from patients with preserved LV function (EF>50%) with sinus rhythm (SR, n=31) or rate-controlled AF (n=24) obtained during surgery for aortic stenosis was studied. Clinical data were mostly balanced without changes in LV function and remodeling. LV myocardium from SR and AF patients showed no changes in fibrosis. In functional studies, systolic Ca2+ transient amplitude of human LV cardiomyocytes (CM) was reduced in AF patients, while diastolic Ca2+ levels and Ca2+ transient kinetics were unaltered. These results were confirmed in LV CM from non-failing donors with AF (n=4) vs. SR (n=8). In addition, normofrequent …
Scholar articles
S Pabel, M Knierim, T Stehle, F Alebrand, M Paulus… - Circulation, 2021