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Multiple anthropogenic activities can exert adverse effects on marine vulnerable ecological components and the ecosystem services they provide to human well-being. Emilia-Romagna (E-R) Region belongs to one of the most industrialized coastal and sea areas of the Italian Northern Adriatic Sea, requiring adequate decision support instruments able to assist authorities to enforce ecosystem-based Marine Spatial Planning (MSP). In this research we combine Cumulative Effects Assessment (CEA) model with marine ecosystem services capacity (MES_Cap) assessment of multiple ecological components (seabed habitats, essential fish habitats, marine mammals and turtles). The geospatial instruments were used for E-R Region's sea space to support the selection of spatially explicit measures to address two marine conservation objectives, i.e. A. preservation of essential fish habitats and B. protection of species of …