Inventors
Jane Grogan, Robert J Johnston, Bryan Irving, Jason Hackney, Xin Yu, Dan Eaton, Kristin Bowles, Laetitia Comps-agrar
Publication date
2018/1/23
Patent office
US
Patent number
9873740
Application number
14333375
Description
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
Scholar articles
J Grogan, RJ Johnston, B Irving, J Hackney, X Yu… - US Patent 9,873,740, 2018
J Grogan, RJ Johnston, B Irving, J Hackney, X Yu… - US Patent 10,611,836, 2020