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This paper presents a methodology taking advantage of the GPOD-SBAS service to study the surface deformation information over high mountain regions. Indeed, the application of the advanced DInSAR over the arduous regions represents a demanding task. We implemented an iterative selection procedure of the most suitable SAR images, aimed to preserve the largest number of SAR scenes, and the fine-tuning of several advanced configuration parameters. This method is aimed at minimizing the temporal decorrelation effects, principally due to snow cover, and maximizing the number of coherent targets and their spatial distribution. The methodology is applied to the Valle d’Aosta (VDA) region, Northern Italy, an alpine area characterized by high altitudes, complex morphology, and susceptibility to different mass wasting phenomena. The approach using GPOD-SBAS allows for the obtainment of mean deformation velocity maps and displacement time series relative to the time period from 1992 to 2000, relative to ESR-1/2, and from 2002 to 2010 for ASAR-Envisat. Our results demonstrate how the DInSAR application can obtain reliable information of ground displacement over time in these regions, and may represent a suitable instrument for natural hazards assessment.