Authors
Bryan H Burmeister, B Mark Smithers, Val Gebski, Lara Fitzgerald, R John Simes, Peter Devitt, Stephen Ackland, David C Gotley, David Joseph, Jeremy Millar, John North, Euan T Walpole, James W Denham
Publication date
2005/9/1
Journal
The lancet oncology
Volume
6
Issue
9
Pages
659-668
Publisher
Elsevier
Description
Background
Resection remains the best treatment for carcinoma of the oesophagus in terms of local control, but local recurrence and distant metastasis remain an issue after surgery. We aimed to assess whether a short preoperative chemoradiotherapy regimen improves outcomes for patients with resectable oesophageal cancer.
Methods
128 patients were randomly assigned to surgery alone and 128 patients to surgery after 80 mg/m2 cisplatin on day 1, 800 mg/m2 fluorouracil on days 1–4, with concurrent radiotherapy of 35 Gy given in 15 fractions. The primary endpoint was progression-free survival. Secondary endpoints were overall survival, tumour response, toxic effects, patterns of failure, and quality of life. Analysis was done by intention to treat.
Findings
Neither progression-free survival nor overall survival differed between groups (hazard ratio [HR] 0·82 [95% CI 0·61–1·10] and 0·89 [0·67–1·19], respectively …
Total citations
Scholar articles
BH Burmeister, BM Smithers, V Gebski, L Fitzgerald… - The lancet oncology, 2005
B Burmeister, M Smithers, V Gebski - Lancet Oncol, 2005