Authors
Andrew RL Stevenson, Michael J Solomon, John W Lumley, Peter Hewett, Andrew D Clouston, Val J Gebski, Lucy Davies, Kate Wilson, Wendy Hague, John Simes, ALaCaRT Investigators
Publication date
2015/10/6
Journal
Jama
Volume
314
Issue
13
Pages
1356-1363
Publisher
American Medical Association
Description
Importance
Laparoscopic procedures are generally thought to have better outcomes than open procedures. Because of anatomical constraints, laparoscopic rectal resection may not be better because of limitations in performing an adequate cancer resection.
Objective
To determine whether laparoscopic resection is noninferior to open rectal cancer resection for adequacy of cancer clearance.
Design, Setting, and Participants
Randomized, noninferiority, phase 3 trial (Australasian Laparoscopic Cancer of the Rectum; ALaCaRT) conducted between March 2010 and November 2014. Twenty-six accredited surgeons from 24 sites in Australia and New Zealand randomized 475 patients with T1-T3 rectal adenocarcinoma less than 15 cm from the anal verge.
Interventions
Open laparotomy and rectal resection (n = 237) or laparoscopic rectal resection (n = 238).
Main Outcomes and Measures
The primary end point was a …
Scholar articles
ARL Stevenson, MJ Solomon, JW Lumley, P Hewett… - Jama, 2015