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Centenarians are the best example of successful ageing, since they have escaped the major age-associated diseases, alzd most are in good mental and physical condition. Heye, Clattdio Franceschi and colleagues discuss bow the study of their immww systems relvals that selleral immune parameters are well consewed, suggesting that a complex vemodelling of most immune parameters occurs with age, rather than a unidirectional deterioration

Over the past three decades, intense imcstigation of the age-related changes occurring in the immune system of experimental animals (mostly rodents) has resulted in the popular concept that ageing is associated with immune deterioration]. The relative abilities to produce antibody and undergo T-cell proliferation have been taken as paradigms of an impaired immune responsiveness with age. Furthermore, a concept has arisen that the cellular, or T-cell, branch suffers …