Authors
Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown‐Borg, Calogero Caruso, Tyler J Curiel, Rafael De Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein, John J Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G Mirisola, James R Mitchell, Giuseppe Passarino, Karl L Rudolph, John M Sedivy, Gerald S Shadel, David A Sinclair, Stephen R Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra, Luigi Fontana
Publication date
2015/8
Source
Aging cell
Volume
14
Issue
4
Pages
497-510
Description
The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic …
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VD Longo, A Antebi, A Bartke, N Barzilai… - Aging cell, 2015