Authors
Tuan Le, Edwina J Wright, Davey M Smith, Weijing He, Gabriel Catano, Jason F Okulicz, Jason A Young, Robert A Clark, Douglas D Richman, Susan J Little, Sunil K Ahuja
Publication date
2013/1/17
Journal
New England Journal of Medicine
Volume
368
Issue
3
Pages
218-230
Publisher
Massachusetts Medical Society
Description
Background
The relationship between the timing of the initiation of antiretroviral therapy (ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of CD4+ T-cell counts is unknown.
Methods
In a prospective, observational cohort of persons with acute or early HIV-1 infection, we determined the trajectory of CD4+ counts over a 48-month period in partially overlapping study sets: study set 1 included 384 participants during the time window in which they were not receiving ART and study set 2 included 213 participants who received ART soon after study entry or sometime thereafter and had a suppressed plasma HIV viral load. We investigated the likelihood and rate of CD4+ T-cell recovery to 900 or more cells per cubic millimeter within 48 months while the participants were receiving viral-load–suppressive ART.
Results
Among the participants who were not receiving ART, CD4 …
Scholar articles
T Le, EJ Wright, DM Smith, W He, G Catano, JF Okulicz… - New England Journal of Medicine, 2013